Title of article :
Synthesis of the spiro fused β-lactone-γ-lactam segment of oxazolomycin
Author/Authors :
Mohapatra، نويسنده , , Debendra K. and Mondal، نويسنده , , Dhananjoy and Gonnade، نويسنده , , Rajesh G. and Chorghade، نويسنده , , Mukund S. and Gurjar، نويسنده , , Mukund K.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2006
Abstract :
An effective synthetic strategy for construction of the novel spiro-bicyclic β-lactone-γ-lactam system present in oxazolomycin has been demonstrated. The 3,4-disubstituted pyrrolidine ring system was constructed via an Evans aldol reaction. The spiro-β-lactone ring was elaborated from a gem-hydroxymethyl moiety that was successfully installed by an aldol followed by a crossed Cannizzaro reaction.
Keywords :
intramolecular Mitsunobu reaction , Crossed Cannizzaro reaction , Garner’s aldehyde , Evans’ aldol reaction , Ruthenium tetroxide oxidation
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
