Title of article :
New compounds via Mannich reaction of cytosine, paraformaldehyde and cyclic secondary amines
Author/Authors :
Pruka?a، نويسنده , , Dorota، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2006
Abstract :
The Mannich reaction of cytosine, paraformaldehyde and cyclic secondary amines in the presence of acetic acid gives 5-(4′-morpholinyl)methylcytosine, 5-(1′-piperidinyl)methylcytosine, 5-(1′-pyrrolidinyl)methylcytosine, 5-(4′-methyl-1′-piperidinyl)methylcytosine, 5-(3′-methyl-1′-piperidinyl)methylcytosine and 5-(2′-methyl-1′-piperidinyl)methylcytosine. These products are quite different from those obtained via cytosine aminomethylation previously described in the literature.
Keywords :
Mannich reaction , Cyclic secondary amines , Paraformaldehyde , Cytosine
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters