Author/Authors :
Li، نويسنده , , Limei and Li، نويسنده , , Guo-You and Ding، نويسنده , , Li-Sheng and Lei، نويسنده , , Chun and Yang، نويسنده , , Li-Bin and Zhao، نويسنده , , Yong and Weng، نويسنده , , Zhiying and Li، نويسنده , , Sheng-Hong and Huang، نويسنده , , Sheng-Xiong and Xiao، نويسنده , , Wei-Lie and Han، نويسنده , , Quan-Bin and Sun، نويسنده , , Han-Dong، نويسنده ,
Abstract :
Three new 6,7-seco-ent-kauranoids (1–3) were isolated and structures were elucidated from Isodon sculponeatus. Diterpenoids 1–3 possessing multicyclic skeletons formed via oxygen atoms are all unprecedented among ent-kauranes. Compound 1 displayed significant cytotoxic activity against K562, A549, and HepG2 human tumor cell lines, with IC50 values of 1.4, 2.3, and 2.0 μM, respectively, equal to the positive control. Plausible pathways for the biosynthesis of 1 and 2 from one related diterpenoid were also postulated.
Keywords :
Isodon sculponeatus , Labiatae , Sculponins A–C , cytotoxicity , NMR data
