Title of article :
Synthesis of 2-aminocyclopropyl pyrrolidines from glycoaminonitriles
Author/Authors :
Declerck، نويسنده , , Delphine and Josse، نويسنده , , Solen and Nhien، نويسنده , , Albert Nguyen Van and Postel، نويسنده , , Denis، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Abstract :
We have developed an expedient method for the synthesis of 2-aminocyclopropyl pyrrolidines from carbohydrate-derived α-aminonitriles involving up to five or six steps, the key step being the titanium-mediated aminocyclopropanation on the aminonitrile moiety, followed by cleavage of the protecting groups.
Keywords :
Glycoaminonitriles , Cyclopropylamine , Titanium isopropoxide , pyrrolidine
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
