Title of article
Synthesis of functionalized hydroxy-thiophene motifs as amido- and sulfonamido-phenol bioisosteres
Author/Authors
Chao، نويسنده , , Jianhua and Taveras، نويسنده , , Arthur G. and Aki، نويسنده , , Cynthia J.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
4
From page
5005
To page
5008
Abstract
Novel highly substituted hydroxy thiophene motifs were designed and synthesized as viable amido phenol and sulfonamido phenol bioisosteres. Hydroxy group-directed regioselective bromination and palladium-catalyzed amination of thienyl bromide via Buckwald protocol are the key elements of the synthetic approach. The hydroxy thiophene-containing compounds displayed good binding inhibitions.
Keywords
Phenol bioisostere , Hydroxy-thiophene , Heteroaryl Buckwald amination , Bioisostere replacement
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1865575
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