Author/Authors :
Luo، نويسنده , , Xiao and Chang، نويسنده , , Ying and Zhang، نويسنده , , Xing-Jie and Pu، نويسنده , , Jian-Xin and Gao، نويسنده , , Xue-Mei and Wu، نويسنده , , Ying-Li and Wang، نويسنده , , Rui-Rui and Xiao، نويسنده , , Wei-Lie and Zheng، نويسنده , , Yong-Tang and Lu، نويسنده , , Yang and Chen، نويسنده , , Guoqiang and Zheng، نويسنده , , Qitai and Sun، نويسنده , , Han-Dong، نويسنده ,
Abstract :
Schilancidilactones A (1) and B (2), two novel tetranortriterpenoids possessing an unprecedented skeleton, have been isolated from the stems of Schisandra lancifolia. Their structures were elucidated on the basis of extensive spectroscopic analysis. The relative configurations of 1 were further determined by single-crystal X-ray crystallography. Compounds 1 and 2 were tested for their cytotoxicity against four tumor cell lines NB4, A549, SH-SY5Y, and PC-3, and compound 1 was further tested for its anti-HIV-1 activity.
Keywords :
Schilancidilactones A and B , Schisandra lancifolia , Tetranortriterpenoid , Anti-HIV activity
