Author/Authors :
Liu، نويسنده , , Zhihua and Qu، نويسنده , , Hongchang and Gu، نويسنده , , Xuyuan and Lee، نويسنده , , Kwang-Soo and Grossman، نويسنده , , Bryan and Kumirov، نويسنده , , Vlad K. and Hruby، نويسنده , , Victor J.، نويسنده ,
Abstract :
A significantly improved thio–Claisen rearrangement method was developed for preparing anti-β-functionalized γ,δ-unsaturated amino acids, which are extremely useful nonproteinogenic amino acids used in chemistry and biology research. The mild reaction condition successfully introduced base labile functional groups into the amino acids with excellent anti/syn selectivities.
