Author/Authors :
Toumi، نويسنده , , Mathieu and Barbazanges، نويسنده , , Marion and Kroll، نويسنده , , Sebastian H.B. and Patel، نويسنده , , Hetal and Ali، نويسنده , , Simak and Coombes، نويسنده , , R. Charles and Barrett، نويسنده , , Anthony G.M.، نويسنده ,
Abstract :
A flexible six-step synthesis of potential cyclin-dependent kinase 2 (CDK2) inhibitors is reported. The synthesis involves the condensation between 3-chloro-4,4-dimethoxy-2-butanone and amidines, which provides acetyl-imidazoles and late stage palladium-catalyzed N-arylation to give the target pyrimidine derivatives.
