A practical method for the regeneration of Kaiser-oxime resin

During the past two decades solid-phase chemistry has developed from a special tool in peptide- and nucleotide chemistry to a routine method in organic synthesis. However, the linker systems of the most popular supports are destroyed irreversibly in the cleavage step and thus the support can be used only once. We report here a simple procedure for the regeneration of the Kaiser-oxime resin, which renders this support one of the most cost-efficient in solid-phase synthesis.