Author/Authors :
Tang، نويسنده , , Xiao-Ji and Yan، نويسنده , , Zhao-Lei and Chen، نويسنده , , Wen-Liang and Gao، نويسنده , , Ya-Ru and Mao، نويسنده , , Shuai and Zhang، نويسنده , , Yan-Lei and Wang، نويسنده , , Yong-Qiang، نويسنده ,
Abstract :
A general and efficient aza-Michael reaction promoted by aqueous sodium carbonate solution has been developed. The reaction has complete mono-alkylation selectivity and proceeds with complete chirality retention for chiral amino esters. With a broad substrate scope, a well-common catalyst and simple operation, the catalytic approach provides a facile, practicable, economical, and environmentally benign method for the synthesis of β-amino carbonyl compounds.
Keywords :
Aqueous sodium carbonate solution , Aza-Michael reaction , ?-Amino carbonyl compounds , Mono-alkylation
