Title of article :
Syntheses of 5′-amino-2′,5′-dideoxy-2′,2′-difluorocytidine derivatives as novel anticancer nucleoside analogs
Author/Authors :
Marc A. Labroli، نويسنده , , Marc A. and Dwyer، نويسنده , , Michael P. and Shen، نويسنده , , Ruichao and Popovici-Muller، نويسنده , , Janeta and Pu، نويسنده , , Qinglin and Richard، نويسنده , , Judson and Rosner، نويسنده , , Kristen and Paruch، نويسنده , , Kamil and Guzi، نويسنده , , Timothy J.، نويسنده ,
Abstract :
A novel class of 5′-amino-2′,5′-dideoxy-2′,2′-difluorocytidine derivatives has been synthesized in order to identify anticancer nucleoside analogs. Several synthetic routes were devised and implemented which relied upon either SN2 displacement or reductive amination to provide the desired derivatives.
Keywords :
nucleoside , Gemcitabine , reductive amination , Anticancer
