Author/Authors :
Hu، نويسنده , , Xiao-Lan and Bian، نويسنده , , Xi-Qing and Wu، نويسنده , , Xin and Li، نويسنده , , Jian-Yong and Hua، نويسنده , , Hui-Ming and Pei، نويسنده , , Yue-Hu and Han، نويسنده , , Ai-Hong and Bai، نويسنده , , Jiao، نويسنده ,
Abstract :
Penioxalamine A (1), a novel prenylated spiro-oxindole alkaloid having a unique seven-membered nitrogen heterocycle system, was isolated from the fungus Penicillium oxalicum TW01-1. The structure of 1 was elucidated on the basis of the spectral data, single-crystal X-ray diffraction, and CD analysis. Compound 1 showed moderate cytotoxicity against HL-60 cell line. The possible biosynthetic pathway of 1 was also proposed.
Keywords :
Penioxalamine A , Prenylated indole alkaloid , cytotoxicity , Penicillium oxalicum
