Author/Authors :
Fiorot، نويسنده , , Rodolfo G. and Allochio Filho، نويسنده , , Joمo F. and Pereira، نويسنده , , Thieres M.C. and Lacerda Jr.، نويسنده , , Valdemar and dos Santos، نويسنده , , Reginaldo B. and Romمo، نويسنده , , Wanderson and Greco، نويسنده , , Sandro J.، نويسنده ,
Abstract :
A clean, efficient and facile one-pot protocol was developed for the synthesis of a series of new aminonaphthoquinones derived from 2-hydroxy-1,4-naphthoquinone (lawsone) by three-component Mannich reaction using catalytic amount of p-TsOH in CH3CN, at room temperature. At the present work, we improved the yield and significantly reduced the reaction time for several Mannich reactions with different amine and aromatic aldehydes using a non-expensive, mild catalyst and suitable solvent.
