Author/Authors :
Su، نويسنده , , Yin-Di and Cheng، نويسنده , , Ching-Hsiao and Chen، نويسنده , , Wu-Fu and Chang، نويسنده , , Yu-Chia and Chen، نويسنده , , Yu-Hsin and Hwang، نويسنده , , Tsong-Long and Wen، نويسنده , , Zhihong and Wang، نويسنده , , Wei-Hsien and Fang، نويسنده , , Lee-Shing and Chen، نويسنده , , Jih-Jung and Wu، نويسنده , , Yang-Chang and Sheu، نويسنده , , Jyh-Horng and Sung، نويسنده , , Ping-Jyun، نويسنده ,
Abstract :
A novel 6,12-dichlorobriarane diterpenoid, briarenolide J (1), was isolated from an octocoral identified as Briareum sp. The structure of briarane 1 was elucidated by spectroscopic methods. Briarenolide J (1) is the first metabolite of a briarane-related natural product found to possess a chlorine atom at C-12 and this compound was found to display inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils with IC50 values of 14.98 and 9.96 μM, respectively.
Keywords :
Octocoral , Briarane , Diterpenoid , Briareum , Briarenolide
