Title of article :
Synthesis of 3-iodobenzo[b]thiophenes via iodocyclization/etherification reaction sequence
Author/Authors :
Kesharwani، نويسنده , , Tanay and Craig، نويسنده , , Jason and Del Rosario، نويسنده , , Cathlene and Shavnore، نويسنده , , Renee and Kornman، نويسنده , , Cory، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2014
Pages :
5
From page :
6812
To page :
6816
Abstract :
An efficient method was developed for the synthesis of benzo[b]thiophene core structure using a two-step, multicomponent reaction resulting in favorable yields. This convergent reaction requires room temperature thus eliminating the harsh reaction conditions usually associated with the synthesis of benzo[b]thiophene ring structures. Used in many drugs that treat conditions such as osteoporosis, asthma, and fungal infections, the benzo[b]thiophene core structure is of extreme importance to medicinal and pharmaceutical research. The key step in this process involves the use of an iodine as a cyclizing agent that acts simultaneously as a catalyst. Alcohols such as alkyl, allyl, propargyl, and benzylic are employed to prepare a diverse library of 3-iodobenzo[b]thiophenes.
Keywords :
multicomponent reaction , iodocyclization , Electrophilic cyclization , green chemistry
Journal title :
Tetrahedron Letters
Serial Year :
2014
Journal title :
Tetrahedron Letters
Record number :
1891392
Link To Document :
بازگشت