Author/Authors :
Xu، نويسنده , , Hua-Dong and Xu، نويسنده , , Ke and Zheng، نويسنده , , Qing and He، نويسنده , , Wei-Jie and Shen، نويسنده , , Meihua and Hu، نويسنده , , Wen-Hao، نويسنده ,
Abstract :
An efficient and convenient protocol has been developed for ether bond formation in mild conditions. A mixture of primary/secondary ester and allylic/benzylic halide in tetrahydrofuran was treated with KOtBu at room temperature to give ether in high yield. This step economic method enabled direct alkylation of the acyl group masked O-nucleophiles. Application of this method in carbohydrate synthesis was feasible and chemo-selectivity can be achieved.
Keywords :
Step economy , Ether , O-alkylation , etherification , potassium tert-butoxide
