Author/Authors :
Liu، نويسنده , , Xiong-Wei and Yang، نويسنده , , Jun and Yang، نويسنده , , Chao and Han، نويسنده , , Wenyong and Liu، نويسنده , , Xiong-Li and Zhou، نويسنده , , Ying and Yu، نويسنده , , Zhang-Biao and Yuan، نويسنده , , Wei-Cheng، نويسنده ,
Abstract :
A new methodology was developed for the synthesis of spirocyclic oxindoles bearing polyfunctional dihydropyrrole units via an organocatalytic tandem Michael/cyclization sequence. Products bearing adjacent quaternary–tertiary stereocenters were smoothly obtained in high yields (up to 97% yield) with excellent diastereoselectivities up to >20/1.
Keywords :
Spirocyclic oxindoles , Dihydropyrrole , organocatalysis , Michael/cyclization , Quaternary–tertiary stereocenters
