Molecular mechanisms of sweet taste. Part 6: the sweet protein, Monellin

A computer modelling study of the host-guest relationship between Monellin, a sweet protein, and the suggested receptor, an α-helical protein, has revealed an excellent fit, within a cavity of the Monellin conformation. The parameters and stereoselective interactions for sweetness are in accord with our previous data on a range of low molecular weight sweeteners. The AHs/Bs is assigned to either Lys-4(A)/Glu-48(B) or Lys-4(A)/Glu-50(B).