Title of article :
Synthesis, structural characterization and anticarcinogenic activity of a new Gly–Gly dipeptide derivative: Methyl 2-(2-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)acetate
Author/Authors :
Yin، نويسنده , , Ping and Hu، نويسنده , , Mao-Lin and Hu، نويسنده , , Li-Chuan، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
A new anticarcinogenic Gly–Gly dipeptide derivative, methyl 2-(2-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido) acetate, has been synthesized and identified by means of elemental analysis, IR, 1H NMR, 13C NMR, DSC–TGA and X-ray diffraction. It crystallizes in space group P−1 with a = 4.873(4), b = 9.118(7), c = 12.564(10) Å, α = 97.048(15)°, β = 96.159(16)°, γ = 104.987(15)°, Z = 2, V = 533.6(7) Å3, C9H10FN3O5, Mr = 259.2, Dc = 1.613 g/cm3, μ = 0.143 mm−1, F(0 0 0) = 268, R = 0.0626 and wR = 0.1284. In solid state, two adjacent molecules of the title compound are tied to form analogous antiparallel β-sheet arrangement typical of the Gly–Gly dipeptide sequence. The biological test shows that the title compound has certain anticarcinogenic activity, and the cyclic voltammetry test shows the title compound interacts with DNA more strongly than 5-fluorouracil does.
Keywords :
Methyl 2-(2-(5-fluoro-2 , Gly–Gly dipeptide , 4-dioxo-3 , anticarcinogenic activity , thermal analysis , crystal structure , 4-dihydropyrimidin-1(2H)-yl)acetamido)acetate , Cyclic voltammograms
Journal title :
Journal of Molecular Structure
Journal title :
Journal of Molecular Structure