Title of article :
Vibrational study of acetazolamide polymorphism
Author/Authors :
Baraldi، نويسنده , , C. and Gamberini، نويسنده , , M.C. and Tinti، نويسنده , , A. and Palazzoli، نويسنده , , F. and Ferioli، نويسنده , , V.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2009
Pages :
9
From page :
88
To page :
96
Abstract :
In this paper, an acetazolamide vibrational study has been conducted to identify its two known polymorphic forms (A and B). Other techniques, such as Hot-stage and X-ray powder diffraction, have been also reported. Moreover, the thermodynamic and spectroscopic behaviour of ground form A has been investigated. In this study, acetazolamide form A was ground at different times (1, 5, 10, 15, 20 min) and FT-IR/ATR and DSC measurements have been carried out. The grinding process, decreasing the particle sizes, has been induced a polymorphic transformation of A to B form. ermine the B in A percentages, calibration curves have been performed by FT-Raman measurements.
Keywords :
IR spectroscopy (FT-IR/ATR) , Acetazolamide , RAMAN MICROSCOPY , X-ray powder diffraction (XRPD) , Grinding
Journal title :
Journal of Molecular Structure
Serial Year :
2009
Journal title :
Journal of Molecular Structure
Record number :
1965917
Link To Document :
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