Title of article :
Nanostructured lipid carriers for parenteral delivery of silybin: Biodistribution and pharmacokinetic studies
Author/Authors :
Jia، نويسنده , , Lejiao and Zhang، نويسنده , , Dianrui and Li، نويسنده , , Zhenyu and Duan، نويسنده , , Cunxian and Wang، نويسنده , , Yancai and Feng، نويسنده , , Feifei and Wang، نويسنده , , Feihu and Liu، نويسنده , , Yue and Zhang، نويسنده , , Qiang، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2010
Pages :
6
From page :
213
To page :
218
Abstract :
The objective of the present study was to explore the potential of nanostructured lipid carriers (NLCs) for the intravenous delivery of silybin, a poorly water-soluble antihepatopathy agent. Silybin-NLC was prepared by the method of emulsion evaporation at a high temperature and solidification at a low temperature. The resultant NLC had a mean size 232.1 nm and a zeta potential of −20.7 mV. The differential scanning calorimetry (DSC) analysis indicated that silybin was not in crystalline state in the NLC. In vitro data for release of the drug from silybin-NLC was fitted to a two-stage exponential kinetic model. The pharmacokinetics and tissue distribution of silybin-NLC were studied after intravenous administration using New Zealand rabbits and Kunming mice as experimental animals. A silybin control solution was studied parallelly. Silybin-NLC showed higher AUC (area under tissue concentration–time curve) values and circulated in the blood stream for a longer time compared with silybin solution. The tissue distribution demonstrated a high uptake of silybin-NLC in RES organs particularly in liver. These results indicate that NLC is a potential sustained release and targeting system for silybin.
Keywords :
Nanostructured lipid carriers , Pharmacokinetics , Silybin , tissue distribution , In vitro release
Journal title :
Colloids and Surfaces B Biointerfaces
Serial Year :
2010
Journal title :
Colloids and Surfaces B Biointerfaces
Record number :
1971793
Link To Document :
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