Title of article :
Structural changes of β-carotene and some retinoid pharmaceuticals induced by environmental factors
Author/Authors :
Roman، نويسنده , , Maciej and Kaczor، نويسنده , , Agnieszka and Dobrowolski، نويسنده , , Jan Cz. and Baranska، نويسنده , , Malgorzata، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2013
Pages :
10
From page :
99
To page :
108
Abstract :
Four pharmaceuticals (β-carotene (1), retinoic acid (2), isotretinoin (3), and etretinate (4)) were analyzed using Raman spectroscopy and quantum-chemical calculations followed by potential energy distribution (PED) analysis to gain deeper insight into the experimental vibrational spectra. Small shifts of characteristic bands of (4) upon change of solvent and pH were interpreted as a result of molecular aggregation. Temperature-dependent studies on the Raman spectrum of (1) were performed in the temperature region of −150 °C to +150 °C. The observed small shifts in the experimental spectra upon heating were explained by increase of the high-energy conformers (of the trans type) in the population of (1) related to weakening of the intermolecular interactions that enables rotation of the terminal rings with respect to the polyene chain. Deconvolution of the ν1 band showed changes in intensity and position of the deconvoluted bands with the increase of temperature.
Keywords :
Etretinate , Aggregation , isotretinoin , ?-Carotene , Solvent effect , Retinoic acid
Journal title :
Journal of Molecular Structure
Serial Year :
2013
Journal title :
Journal of Molecular Structure
Record number :
1973397
Link To Document :
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