Nonenzymatic glucose sensor based on nickel(II)oxide/ordered mesoporous carbon modified glassy carbon electrode

A highly sensitive and selective nonenzymatic glucose sensor based on electrodepositing NiO nanoparticles on ordered mesoporous carbon (named as NiO/OMC) modified glassy carbon electrode (GCE) was constructed. The synthesized OMC was characterized by X-ray diffraction, and the morphology images of OMC nanoparticle and NiO/OMC nanocomposite were characterized by scanning electron microscope. Electrochemical behaviors of glucose at the NiO/OMC/GCE were investigated by cyclic voltammetry and amperometry, and the modified electrode showed excellent electrochemical activity toward the oxidation of glucose. At the optimum conditions, the calibration curve for glucose determination was linear in the range of 2–1000 μM with a fast response time (<2 s), and a high sensitivity of 834.8 μA mM−1 cm−2 and a low detection limit (S/N = 3) of 0.65 μM were obtained. In addition, the proposed sensor was successfully applied to analyze glucose level in human blood serum samples.