Title of article :
Synthesis and Antitubercular Activity of N3,N5-Diaryl-4-(5-arylisoxazol-3-yl)-1,4-dihydropyridine- 3,5-dicarboxamide
Author/Authors :
Shafii، B. نويسنده 1Department of Medicinal Chemistry, Faculty of Pharmacy, Azad University, Tehran, Islamic Republic of Iran , , Amini، M. نويسنده 2Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 14174, Islamic Republic of Iran , , Akbarzadeh، T. نويسنده , , Shafiee، A. نويسنده ,
Abstract :
5-Arylisoxazolyl-3-carboxaldehydes were condensed with N-aryl acetoaceta-mide and ammonium acetate in methanol to give N3,N5-diaryl-4-(5-arylisoxazol-3-yl)-1,4-dihydropyridine-3,5-dicarboxamides. All compounds were screened for their antitubercular activity against Mycobacterium tuberculosis (H37Rv). The results for new synthesized compounds showed a moderate activity in comparison to rifampicin.
