Title of article :
Porous poly (lactic-co-glycolide) microsphere sintered scaffolds for tissue repair applications
Author/Authors :
Wang، نويسنده , , Yingjun and Shi، نويسنده , , Xuetao and Ren، نويسنده , , Li and Wang، نويسنده , , Chunming and Wang، نويسنده , , Dong-An، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2009
Abstract :
In this paper, a new route to preparing porous poly (lactic-co-glycolide) (PLGA) scaffolds for bone tissue repair applications was developed. Novel porous PLGA scaffolds were fabricated via microsphere sintered technique and gas forming technique. Ammonium bicarbonate was used to regulate porosity of these porous scaffolds. Porosity of the scaffolds, and cell attachment, viability and proliferation on the scaffolds were evaluated. The results indicated that PLGA porous scaffolds were with the porosity from around 30% to 95% by regulating ammonium bicarbonate content from 0 to 10%. We also found that PLGA porous microsphere scaffolds benefited cell attachment and viability. Taken together, the achieved porous scaffolds have controlled porosity and also support mesenchymal stem cell proliferation, which could serve as potential scaffolds for bone repair applications.
Keywords :
Scaffold , Porous , Microsphere , Poly (lactic-co-glycolide)
Journal title :
Materials Science and Engineering C
Journal title :
Materials Science and Engineering C