Author/Authors :
Ejtehadifa، Mostafa نويسنده Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. , , Shamsasenjan، Karim نويسنده Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran. , , Movassaghpour، Aliakbar نويسنده Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. , , Akbarzadehlaleh، Parvin نويسنده Pharmaceutical Biotechnology Department, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran , , Dehdilani، Nima نويسنده Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran , , Abbasi، Parvaneh نويسنده Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran , , Molaeipour، Zahra نويسنده Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. , , Saleh، Mahshid نويسنده Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. ,
Abstract :
Although physiological and pathological role of hypoxia have been appreciated in
mammalians for decades however the cellular biology of hypoxia more clarified in the past
20 years. Discovery of the transcription factor hypoxia-inducible factor (HIF)-1, in the
1990s opened a new window to investigate the mechanisms behind hypoxia. In different
cellular contexts HIF-1 activation show variable results by impacting various aspects of cell
biology such as cell cycle, apoptosis, differentiation and etc. Mesenchymal stem cells
(MSC) are unique cells which take important role in tissue regeneration. They are
characterized by self-renewal capacity, multilineage potential, and immunosuppressive
property. Like so many kind of cells, hypoxia induces different responses in MSCs by HIF-
1 activation. The activation of this molecule changes the growth, multiplication,
differentiation and gene expression profile of MSCs in their niche by a complex of signals.
This article briefly discusses the most important effects of hypoxia in growth kinetics,
signalling pathways, cytokine secretion profile and expression of chemokine receptors in
different conditions.
