Author/Authors :
Deepu، Channegowda V. نويسنده Department of Studies in Chemistry, Yuvaraja’s College, University of Mysore, Mysore-570005, India , , Raghavendra، Goravanahalli M. نويسنده Department of Studies in Chemistry, Manasagangothri, University of Mysore, Mysore-570006, India , , Rekha، Nanjappagowda D. نويسنده PG Department of Biotechnology, JSS College of Arts, Commerce and Science, Ooty Road, Mysore-25, India , , MANTELINGU، K. نويسنده , , Rangappa، Kanchugarakoppal S. نويسنده Department of Studies in Chemistry, Manasagangothri, University of Mysore, Mysore-570006, India , , Bhadregowda، Doddamedur G. نويسنده Department of Studies in Chemistry, Yuvaraja’s College, University of Mysore, Mysore-570005, India ,
Abstract :
Novel 1,5-benzothiazepin-4-(5H)-one derivatives (8a-8g) have been synthesized by intramolecular cyclization of 6 using propyl phosphonic anhydride (T3P) as a cyclodehydrating agent. The anti-angiogenic and anti-oxidant properties of the new derivatives were then evaluated. Compounds 8b, 8d, 8e, 8f and 8g exhibited very good inhibition of capillary proliferation, thus proving their anti-angiogenic properties. In addition, the in vitro antioxidant activities of these compounds were evaluated using diphenyl picryl hydrazine (DPPH), OH-, metal ion-chelating and NO (nitric oxide) assays, and the results compared with butylated hydroxytoluene (BHT), a well known anti-oxidant. Compounds 8a-8g showed excellent free-radical scavenging activities in the metal ion-chelating assay, and compounds 8f and 8g showed nitric oxide radical scavenging properties at a concentration of 20-100 µg/mL, and are thus more potent than BHT.
