Author/Authors :
Besharat، Mahsa نويسنده Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran , , Tabandeh، Afsane نويسنده Golestan Research Center for Infertility, Golestan University of Medical Sciences, Gorgan, Iran , , Keshtkar، Abbasali نويسنده Endocrine and Metabolic Research Institute, Tehran University of Medical Sciences, Tehran, Iran , , Mobasheri، Elham نويسنده Golestan Research Center of Congenital Abnormality, Golestan University of Medical Sciences, Gorgan, Iran , , Besharat، Sima نويسنده Department of Obstetrics and Gynecology, Faculty of Medicine, Shahed University of Medical Sciences, Tehran, Iran , , Joshaghani، Hamidreza نويسنده Golestan Research Center of Gastero Enterology and Hepatology, Golestan University of Medical Sciences. Gorgan, IR Iran ,
Abstract :
Background: It has been reported that 15-20% of parous female have experienced at
least one miscarriage, while 3% of them have experienced two miscarriages. The goal of
this study was to evaluate the plasma level of coagulation factors in women with a history
of spontaneous abortions.
Materials and Methods: In this case-control study, 82 women with a history of two
or more abortions referred to the six private gynecologic clinics in Gorgan city without
any structural abnormality were recruited during 2011-2012. Plasma levels of antithrombin
III (ATIII) using colorimetric assay, protein C, protein S, factor V Leiden and lupus
anticoagulant (LAC) using coagulation method were measured. The control group was
women with a history of normal delivery and no abortions. Those under anti-coagulant
therapy were excluded from the study. Data were entered into the computer using the
Statistical Package for the Social Sciences (SPSS, SPSS Inc., Chicago, IL, USA) version
16 and analyzed by Chi-square, t test and non-parametric tests.
Results: At least one abnormality was reported in 35 cases (42.7%). Among them, protein
C deficiency was the most prevalent (30.5%). ATIII was abnormal in 17.1% and
lupus anti-coagulant was abnormal in 8.5%. Factor V Leiden was normal in all cases
and protein S deficiency was only seen in one case.
Conclusion: We suggest to perform these tests in regards to the thrombophilia in
