Author/Authors :
Akrami Mohajeri، Fateme نويسنده Department of Social Medicine, Rafsanjan Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran , , Amiri، Asieh نويسنده Iranian Research Center for Zoonotic Disease, Shahid Sadoughi University of Medical Sciences, Yazd, Iran , , Khorramdel Azad ، Hossein نويسنده Iranian Research Center for Zoonotic Disease, Shahid Sadoughi University of Medical Sciences, Yazd, Iran , , Ahmadi، Zahra نويسنده Department of Mathematics , , Asadollahi، Zahra نويسنده Molecular Medicine Research Center, Rafsanjan University of Medical Science, Rafsanjan, Iran , , Rezaeian، Mohsen نويسنده Department of Epidemiology, Occupational Environment Research Center, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Ir Rezaeian, Mohsen , Fallah، Aziz A. نويسنده Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran , , Ghalebi ، Seyed Razi نويسنده Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran ,
Abstract :
Abstract
Introduction: Aflatoxins, known as causative factors of hepatic and extra-hepatic carcinogenesis within humans, are extremely teratogenic, mutagenic, toxic, and carcinogenic compounds.
Materials & Methods: This study was undertaken to determine the occurrence of aflatoxin M1 (AFM1) in 40 raw milk and 47 pasteurized milk samples collected during spring and winter. In order to analyze the samples, the Enzyme-linked Immunosorbent Assay (ELISA) procedure was used. The statistical methods used in this study were based on normal confidence intervals and analysis of variance (ANOVA).
Results: Aflatoxin M1 was detected in 97.5% of the raw milk ranging from 6.52 to 68.17 ng/l and 95.7% of the pasteurized milk, ranging from 0.8 to 58.13 ng/l. Toxin levels in 10% of the raw milk and 2.1% of the pasteurized milk samples exceeded the Iranian national standard limit i.e. 50 ng/l. Due to seasonal variations, mean concentration of AFM1 in the samples collected in winter was significantly (P < 0.03) higher than those collected in the summer.
Conclusion: Large amount of AFM1 in milk samples might be a potential hazard for the public health. Reducing the levels of AFB1 in animal feedstuffs can be regarded as the initial step to control the transfer of AFM1 to humans.
