Title of article :
Modulation of NR1 subunit of N-methyl-D-aspartate receptor by ovariectomy and passive avoidance learning.
Author/Authors :
Taherianfard، Mahnaz نويسنده Department of Physiology, Faculty of Veterinary Medicine, Shiraz University, Shiraz, Iran Taherianfard, Mahnaz , Sharifi ، Maryam نويسنده The Research Center for Modeling in Health, Institute for future studies in Health, Kerman University of Medical Sciences, Kerman, Iran , , Tadjali، Mina نويسنده Department of Histology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran Tadjali, Mina , Kohkiloezadeh، Mahboubeh نويسنده Department of Surgery, School of Veterinary Medicine, Shiraz University, Shiraz, Iran Kohkiloezadeh, Mahboubeh
Issue Information :
فصلنامه با شماره پیاپی 0 سال 2012
Pages :
6
From page :
140
To page :
145
Abstract :

Background: Learning and memory are the most intensively studied subjects in neuroscience. Two sites of mammalian brain which are important in learning and memory are CA1 region of hippocampus and Purkinje cell layer of cerebellum. So, the aim of present investigation was to study of the effect of ovariectomy and passive avoidance learning on NR1 subunit of N-methyl-D-aspartate (NMDA) receptor distribution in CA1 region of hippocampus and Purkinje cell layer of cerebellum.
Methods:Twenty four Sprague-Dawley rats were used in 4 groups: control-1 (intact without learning), control-2 (intact with learning), ovariectomy without learning, and ovariectomy with learning. Immunohistochemical procedure was used for determination of NR1 subunit of NMDA receptor. A shuttle box apparatus used for passive avoidance learning procedure. The determination of color intensity was cone by Photoshop software.
Results:Immunohistological findings indicated that ovariectomy has a negative effect on density of NR1 subunit of NMDA receptors in two brain regions. Passive avoidance learning significantly increased density of NR1 subunit of NMDA receptors in two brain regions.
Conclusion:
The results indicated that the sex hormone can modulate function and expression of the NR1 subunit of NMDA receptor in CA1 region of hippocampus and Purkinje cell layer of cerebellum.

Journal title :
Iranian Journal of Neurology
Serial Year :
2012
Journal title :
Iranian Journal of Neurology
Record number :
2385729
Link To Document :
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