Author/Authors :
Fayaz، Ahmad نويسنده WHO Collaborating Center for Reference and Research on Rabies, Pasteur Institute of Iran, Tehran, Iran. Fayaz, Ahmad , Simani، Susan نويسنده WHO Collaborating Center for Reference& Research on Rabies, Pasteur Institute of Iran, Simani, Susan , Fallahian، Vida نويسنده , , Eslamifar، Ali نويسنده , , Hazrati، Mahboob نويسنده , , Farahtaj، Firoozeh نويسنده WHO Collaborating Center for Reference& Research on Rabies, Pasteur Institute of Iran, Farahtaj, Firoozeh , Howaizi، Nader نويسنده WHO Collaborating Center for Reference and Research on Rabies, Pasteur Institute of Iran, Tehran, IR Iran , , Biglari، Peivand نويسنده WHO Collaborating Center for Reference and Research on Rabies, Pasteur Institute of Iran, Tehran, Iran. Biglari, Peivand
Abstract :
مقدمه: بيماري هاري يك عفونت كشنده بوده و پروفيلاكسي بعد از تماس با سرم و واكسن روش انتخابي پيشگيري از بيماري هاري است.
موارد: در اينجا ما سطح آنتي بادي ضدهاري را در سرم و خون بند ناف زنان بارداري كه توسط حيوانات مشكوك گزيده شده بودند، بعد از تجويز سرم و واكسن ضدهاري گزارش نموديم. بين سال هاي 1389-1386، تعداد شش نفر خانم باردار 35-22 ساله در بخش درمان و پيشگيري انستيتو پاستور ايران در تهران پذيرش شدند. دو نفر در سه ماهه اول، يك نفر سه ماهه دوم و سه نفر در سه ماهه سوم حاملگي بودند. فاصله گزيدگي تا زايمان 265-5 روز (متوسط 121 روز) بود.
نتيجه گيري: ميزان سطح ايمونوگلوبولين مادر و نوزاد مساوي نبود، اما همه نوزادان سطح كافي ايمونوگلوبولين (05/0 واحد بين المللي در ميلي ليتر) را داشتند به جز موردي كه فاصله گزيدگي مادر تا زايمان تنها 5 روز بود كه زمان براي ايمونيزاسيون كافي نمي باشد.
Abstract :
Background: Rabies is a fatal infectious disease and rabies post-exposure prophylaxis is the method of choice for prevention of human rabies.
Case series: We report rabies antibody levels in cord blood and also in serum of pregnant women who were bitten by suspected animals to rabies and were immunized by purified Vero cell rabies vaccine (PVRV) and Human Rabies immunoglobulin (HRIG) serum. During the years of 2007-2010, six pregnant women by the age range of 22-35 years were admitted in treatment and prevention of rabies center in Pasture institute of Iran, in Tehran. Among them two cases were at first trimester, one at second trimester and three at third trimester of conception. The interval between biting with delivery was 5-265 days (mean 121 days).
Conclusion: Results of immunoglobulin illustrate that levels of rabies antibody in maternal sera with the fetus are not equal and uniform but it is proved that baby will find efficient immunity as well with minimum protective level of 0.5 IU/ml in all cases except a newborn whom had been born just 5 days after the mother’s immunization and in a shorter time than the appropriate immunization of the mother who had received her second vaccination courses.
