Author/Authors :
Shirali، Saeed نويسنده Department of Laboratory Sciences, School of Paramedical Sciences, Hyperlipidemia Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran , , Shokri Mashhadi، Nafiseh نويسنده Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan , , Ashtary Larky، Damoon نويسنده Department of Biochemistry, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran , , Safania، Tahereh نويسنده Department of Physical Education and Sport Sciences,
Islamic Azad University, Ayatollah Amoli Branch, Amol, IR
Iran , , Barari، Alireza نويسنده Asisstant professor , Science and Research Branch, Ayatollah Amoli Branch, Islamic Azad University ,
Abstract :
Silymarin has powerful antioxidant properties, but its effects on
athletic performance are poorly understood. The present study was
undertaken to evaluate the effects of 4 weeks of endurance or strength
exercise, with or without silymarin, on body composition, paraoxonase
(PON), leptin and adiponectin levels in untrained men. A total of 45
untrained men were divided into 5 groups (n = 9): endurance training
with placebo (ET + P), endurance training with 140 mg of silymarin/day
(ET + S), strength training with placebo (ST + P), strength training
with 140 mg of silymarin/day (ST + S) and placebo (C). Anthropometrical
and VO2max measurements and ELISA assay for PON, leptin and adiponectin
levels were performed at the beginning and after the 4-week of the study
There was a significant decrease in weight and body mass index in the ET
+ P and ET + S groups and increases in ST + P and ST + S (P <
0.05) groups. Body fat declined in all four trained groups (P <
0.001). Peak oxygen uptake (VO2max) improved in both ET + P and ET + S
subjects. Paraoxonase (PON) was increased only in ET + S group (P
< 0.05). Adiponectin was increased in all four groups (P <
0.05). Circulating leptin remained unchanged within all interventions.
The present study has demonstrated that a combination of exercise and
silymarin can improve body composition and adiponectin levels.
