Title of article :
Polymorphism of IL-28B Gene (rs12979860) in HCV Genotype 1 Patients Treated by Pegylated Interferon and Ribavirin
Author/Authors :
Safarnezhad Tameshkel، Fahimeh نويسنده Gastrointestinal & Liver Disease Research Center (GILDRC),Iran University of Medical Sciences,Tehran,Iran , , Karbalaie Niya، Mohmmad Hadi نويسنده Department of Virology,Iran University of Medical Sciences,Tehran,Iran , , Sohrabi، Masuodreza نويسنده Gastrointestinal & Liver Disease Research Center (GILDRC),Iran University of Medical Sciences,Tehran,Iran , , Panahi، Mahshid نويسنده Gastrointestinal & Liver Disease Research Center (GILDRC),Iran University of Medical Sciences,Tehran,Iran , , Zamani، Farhad نويسنده Gastrointestinal & Liver Disease Research Center (GILDRC),Iran University of Medical Sciences,Tehran,Iran , , Imanzade، Farid نويسنده Department of Pediatrics,Shahid Beheshti University of Medical Sciences,Tehran,Iran , , Rakhshani، Nasser نويسنده Gastrointestinal & Liver Disease Research Center (GILDRC),Department of Pathology,Iran University of Medical Sciences,Tehran,Iran ,
Issue Information :
فصلنامه با شماره پیاپی سال 2016
Pages :
6
From page :
216
To page :
221
Abstract :
Background: Nowadays, the immune response to hepatitis C (HCV) treatment has become a crucial issue mostly due to the interleukin 28B (IL28B) polymorphism effects in chronic HCV patients. The aim of this study was to detect the polymorphism of IL28B gene (rs12979860) in HCV genotype 1 patients treated with pegylated Interferon and Ribavirin. Methods: From the 2010 to 2012, a total of 115 peripheral blood mononuclear cells (PBMCs) of HCV patients who presented to Gastrointestinal Liver Disease Research Center (GILDRC), Firoozgar Hospital, Tehran, Iran were enrolled in this retrospective cross sectional study. Samples were then categorized based on the presence of sustained virologic response (SVR and noSVR). Variables including age, gender, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels of the two groups were investigated based on different IL28B genotypes. Results: Analysis by the variables of age and gender showed a mean age ± SD of 42.1±14.0 and gender variability of 44 females (38.2%) and 71 males (61.8%). Adding up these results, the analysis of ALT levels revealed that there was between 293 and 14 mg/ml; AST levels ranged between 217 and 17 mg/ml; the viral load (HCV RNA) ranged between 7,822,000 and 50 IU/ml; the prevalence of CC, CT and TT genotypes were 90.9%, 54% and 25.0%. Conclusion: IL28B polymorphism has an effective impact on the therapeutic response to ribavirin and peginterferon combination therapy in chronic HCV patients infected by different genotypes. This polymorphism is crucial in natural clearance.
Keywords :
Chronic HCV infection , Interleukin 28B polymorphism , Sustained virologic response
Journal title :
Iranian Journal of Pathology (IJP)
Serial Year :
2016
Journal title :
Iranian Journal of Pathology (IJP)
Record number :
2398214
Link To Document :
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