Author/Authors :
Aksaray Sebahat نويسنده Department of Clinical Microbiology, Haydarpasa Numune Hospital, Istanbul, Turkey , Senbayrak Seniha نويسنده Department of Infectious Diseases and Clinical
Microbiology Haydarpasa Numune Training and Research Hospital,
Istanbul, Turkey , Serkan Boz Efe نويسنده Department of Microbiology and Clinical Microbiology,
Haydarpasa Numune Training and Research Hospital, Istanbul,
Turkey , Cevan Simin نويسنده Public Health Laboratory, Bolu, Turkey , Inan Asuman نويسنده Department of Infectious Diseases and Clinical
Microbiology Haydarpasa Numune Training and Research Hospital,
Istanbul, Turkey , Ozturk Engin Derya نويسنده Department of Infectious Diseases and Clinical
Microbiology Haydarpasa Numune Training and Research Hospital,
Istanbul, Turkey , Dosoglu Nilgun نويسنده Department of Microbiology and Clinical Microbiology,
Haydarpasa Numune Training and Research Hospital, Istanbul,
Turkey , Cobanoglu Naz نويسنده Department of Microbiology and Clinical Microbiology,
Haydarpasa Numune Training and Research Hospital, Istanbul,
Turkey , Dagli Ozgur نويسنده Department of Infectious Diseases and Clinical
Microbiology, Bursa Sevket Yilmaz Training and Research Hospital,
Bursa, Turkey , Davarci Ismail نويسنده Department of Microbiology and Clinical Microbiology,
Goztepe Training and Research Hospital, Istanbul,
Turkey
Abstract :
Background Extended spectrum beta-lactamase (ESBL) producing
organisms causing urinary tract infections are increasing in incidence
and becoming a serious health problem due to their resistance to large
number of antibiotics. Objectives To investigate the ESBL prevalence of
Escherichia coli and Klebsiella
spp. which are isolated from urine samples for both in and
outpatients with their resistance profiles. Methods From 2004 to 2012, a
total of 13975 isolates (12897 E. coli, 1078
Klebsiella spp.) were included in this study. The
antibiotic susceptibility was tested using Kirby–Bauer disk diffusion
method and Vitek2 System (bioMerieux, France) according to CLSI. Results
Our data showed a significant increasing in ESBL prevalence from 12.5%
to 44.7% (P < 0.001) for inpatients; from 9.6% to 22.8% (P
< 0.001) for outpatients in E. coli and from
25% to 60.5% (P < 0.003) for inpatients; from 12% to 25% (P
< 0.095) for outpatients in Klebsiella spp.
For E. coli, the increase was significantly high in
both of males and females (P < 0.001). However, for
Klebsiella spp. it was significantly high in male
patients (P < 0.001). The resistance rates of antibiotics for the
ESBL producing E. coli, and Klebsiella
spp. showed a significant increase. These rates were higher
than 70% for fluoroquinolones, amoxicillin-clavulanic acid and
trimethoprim-sulfamethoxazole. Even carbepenem resistance reached to 7%
in the outpatients and 15% in inpatients for ESBL producing
Klebsiella spp. Conclusions Our study demonstrated a
significant increase in the prevalence of ESBL producing E.
coli and Klebsiella spp. and a remarkable
carbapenem resistance trend in the ESBL producing Klebsiella
spp. isolated from urine samples.
