Application of Cu(II) Nanocomplex Modified Graphite Screen Printed Electrode to Improve the Sensitivity for Norepinephrine Detection

A Cu(II) nanocomplex, [CuCl2(salophen)].H2O[salophen=o-phenylenediaminebis(salicylidenaminato)], was synthesized. The electrochemical properties of the as-prepared Cu(II) nanocomplex modified graphite screen printed electrode (Cu/SPE) were investigated using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Moreover, as a nanosensor for the determination of norepinephrine the Cu/SPE exhibited excellent electrocatalytic activity for the oxidation of norepinephrine with a faster electron-transfer rate. The DPV technique was used for the trace determination of norepinephrine. The dependence of current vs. concentration was linear from 0.3 to 300.0 μM with a regression coefficient of 0.9992, and the detection limit of norepinephrine was 0.09 μM. Finally, the method was applied to the selective and precise analysis of norepinephrine in norepinephrine injection.