Author/Authors :
Motamed, F Department of Gastroenterology, Children's Medical Center Hospital - Tehran University of Medical Sciences, Tehran , Eftekhari, K Department of Pediatrics - Mousavi Hospital - Zanjan University of Medical Sciences, Zanjan , Kiani, MA Department of Gastroenterology, Children's Medical Center Hospital - Tehran University of Medical Sciences, Tehran , Rabbani, A Department of Endocrinology - Children's Medical Center Hospital - Tehran University of Medical Sciences, Tehran, Iran
Abstract :
A 14 year old female complained of abdominal pain and distention with vomiting. The physical exam showed
thyroid enlargement and ascites. The imaging evaluation demonstrated a large ovarian cyst. Laboratory tests
depicted hypothyroidism and marked elevation of Carbohydrate antigen 125 (CA-125) levels. As the bone age
was 10 years, more retarded than the chronological age, Van Wyk and Grumbach syndrome was suspected.
Treatment with thyroid hormone was initiated and the condition improved dramatically with disappearance of
symptoms and signs 5 weeks later.
Keywords :
Ovarian cyst , Hypothyroidism , CA-125 , Van Wyk , Grumbach syndrome
