Title of article :
Berberine protects against glutamate-induced oxidative stress and apoptosis in PC12 and N2a cells
Author/Authors :
Sadeghnia, Hamid Reza Division of Neurocognitive Sciences - Psychiatry and Behavioral Sciences Research Center - Mashhad University of Medical Sciences , Kolangikhah, Monireh Pharmacological Research Center of Medicinal Plants - Mashhad University of Medical Sciences , Asadpour, Elham Anesthesiology and Critical Care Research Center - Shiraz University of Medical Sciences , Forouzanfar, Fatemeh Pharmacological Research Center of Medicinal Plants - Mashhad University of Medical Sciences , Hosseinzadeh, Hossein Department of Pharmacodynamics and Toxicology - School of Pharmacy - Mashhad University of Medical Sciences
Abstract :
Objective(s): Neurodegenerative diseases have been associated with glutamatergic dysfunction. Berberine, an isoquinoline alkaloid broadly present in different medicinal herbs, has been reported to have neuroprotective effect. In the present study, the effects of berberine against glutamate-induced oxidative damage and apoptosis were investigated.
Keywords :
Apoptosis , Berberine , Glutamate cytotoxicity , Neuroprotection , Oxidative injury
Journal title :
Astroparticle Physics
