Author/Authors :
Xiang, Qiong Institute of Medicine - Medical Research Center - Jishou University - Hunan, China , hui Li, Xian Institute of Medicine - Medical Research Center - Jishou University - Hunan, China , Yang, Bo Institute of Medicine - Medical Research Center - Jishou University - Hunan, China , Fang, Xin-xing Institute of Medicine - Medical Research Center - Jishou University - Hunan, China , Jia, Jing Institute of Medicine - Medical Research Center - Jishou University - Hunan, China , Dong, Yu-chun Institute of Medicine - Medical Research Center - Jishou University - Hunan, China , Yang, Cheng Ou Institute of Medicine - Medical Research Center - Jishou University - Hunan, China , cheng Wang, Guang College of Chemistry and Chemical Engineering - Jishou University - Hunan, China
Abstract :
Results: The density of dendritic spine was increased significantly in allicin-treated groups and the correspondence slope of fEPSP in TM-induced cognitive deficits group was enhanced and expression of synaptophysin and glutamate receptor-1(GluR1) in hippocampal neurons was up-regulated. Conclusion: The results indicate that allicin plays an important role in synaptic plasticity regulation. These finding showed that allicin could be used as a pharmacologic treatment in TM-induced cognitive deficits.
Keywords :
Allicin , Dendritic spine density , fEPSP , Hippocampus , Synaptic plasticity
