Author/Authors :
Tanha, Kaveh The Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran , Fatemikia, Hossein Department of Physiology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran , Assadi, Majid The Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran , Seyedabadi, Mohammad The Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran
Abstract :
Introduction: The optimal imaging time of a radionuclide scintigraphy is the time at which the organ of interest has the maximum
uptake of the injected radionuclide. This study was performed to investigate the maximum uptake time of 99mTc-DMSA in rat renal
scan.
Methods: Renal scintigraphy was performed with 3 mCi of 99mTc-DMSA. Planar images were acquired every 20 minutes for 8 hours
post-injection using a small-animal SPECT.
Results: Activity and the count rate per pixel (CRPP) of the kidneys peaked 1 h post-injection, plateaued for about 1 h, and declined
time-dependently. Kidney to background ratio (KBR) reached to 61.7% at 1 h after injection and remained almost constant afterwards.
Conclusion: The kidneys had maximum emission and CRPP between 1 to 2 h after 99mTc-DMSA injection, whereas there was no
significant difference between the KBRs after 1 h. Our results showed that image acquisition of 1-2 h post-injection is recommended
for renal scintigraphy with DMSA in rat.
Keywords :
Small animal imaging , Renal scintigraphy , Maximum uptake time , 99mTc-DMSA
