Author/Authors :
Ebrahimpour, Adel Taleghani Hospital - Research Development Committee - School of Medicine - Shahid Beheshti University of Medical Science - Tehran , Okhovatpour, Mohammadali Taleghani Hospital - Research Development Committee - School of Medicine - Shahid Beheshti University of Medical Science - Tehran , Minator Sajjadi, Mohammad Reza Taleghani Hospital - Research Development Committee - School of Medicine - Shahid Beheshti University of Medical Science - Tehran , Makvandi, Kamyar Taleghani Hospital - Research Development Committee - School of Medicine - Shahid Beheshti University of Medical Science - Tehran , Sadighi, Mehrdad Taleghani Hospital - Research Development Committee - School of Medicine - Shahid Beheshti University of Medical Science - Tehran , Saghary, Sepehr Poursina Hospital - Guilan University of Medical Sciences - Rasht, , Sadegh Mousavi, Mohammad Poursina Hospital - Guilan University of Medical Sciences - Rasht, , Mirbolook, Ahmadreza Poursina Hospital - Guilan University of Medical Sciences - Rasht,
Abstract :
Background: Interleukin 6 (IL-6) functions as both a pro-inflammatory cytokine and an
anti-inflammatory cytokine. Objective: To evaluate the levels of IL-6 in patients with
multiple organ dysfunction syndrome (MODS). Methods: Level of IL-6 was assessed
and recorded for 14 days subsequent to the injury in 161 multiple trauma patients.
MODS were diagnosed using Marshal Score. Injury Severity Scoring (ISS) was
measured for all patients. Results: The results of this study indicated that there was a
significant relationship between the level of IL-6 and ISS on the post trauma days
number one and two (P=0.0001). The high level of IL-6 on the post trauma day number
2 was associated with high mortality rate. Conclusion: Our study suggests the second
day as the golden time for measuring the serum levels of IL-6. These findings warn us
to take more health care actions in patients with higher serum levels of IL-6 on the
second day.
Keywords :
IL6 , Prognosis , Multiple Trauma , Multiple Organ Dysfunction , Mortality Rate
