Abstract :
In their recent large, retrospective, cross-sectional
study with 7702 renal-transplant patients, Einollahi et al.
showed that cyclosporine (CsA) absorption (CA) steadily
increases over 3 years post transplant (1). They also indicated
that despite the day-to-day and inter-individual
variability in CA, the CsA levels are routinely monitored
by measuring the predose blood trough level (C0) or the
2-h post-dose level (C2). Their approach was to use the C2/
C0 ratio as a measure of CA because it takes into account
both the elimination and absorption phases, which are
required to identify high and low CsA absorbers (1).
