Author/Authors :
Elyasinia, Fezzeh Department of Surgery - Tehran University of Medical Sciences, Tehran , Chegini, Venus Department of Gynecology and Obstetrics - Tehran University of Medical Sciences, Tehran , Olfat-Bakhsh, Asieh , Pasalar, Parvin Department of Biochemistry - Tehran University of Medical Sciences, Tehran , Aminian, Ali Department of Surgery - Tehran University of Medical Sciences, Tehran
Abstract :
Background: Superoxide radicals are produced during oxidative metabolic
processes, and removed by superoxide dismutase (SOD) enzymes. Controversial
results have been reported regarding the tissue and plasma concentration of SOD
in patients with breast cancer.
Methods: From study participants including 100 women, venous blood
samples were obtained and activity of SOD enzyme was determined. The
comparison was between 50 patients with breast cancer and 50 individuals in
control group.
Results: The activities of SOD in patients with malignancy and control group
were 553.56±53.67 U/gr Hb and 1218.60±98.55 U/gr Hb, respectively (p<0.001).
Patientswith higher stage and nuclear grade had lower SODactivity.
Conclusions: Lower levels of SOD activity was observed in women with
breast cancer compared to healthy individuals. Considering the existing
controversy regarding the SOD level in breast cancer patients, further studies are
suggested to explore the reason of these differences.
