Author/Authors :
Prajapat, Prakash Department of Chemistry - M. L. Sukhadia University, Udaipur, India , Rathore, Krishna K. Department of Chemistry - M. L. Sukhadia University, Udaipur, India , Hussain, Nasir bDepartment of Chemistry - Vidya Bhawan Rural Institute, Udaipur, India , Yogi, Prabhunath Department of Chemistry - Mewar University, Gangrar, Chittorgarh, India , Talesara, G. L. Department of Chemistry - M. L. Sukhadia University, Udaipur, India
Abstract :
In this investigation, the synthesis of benzoxazole based oxygen substituted hydroxylamine functionalized pyrimidines 4a, 4b and pyrimido[4,5-d]pyrimidines 7a, 7b, 9, & 10 is achieved by using 1-(1,3-benzoxazol-2-yl)guanidine as a starting material via multistep routes. Structures of newly synthesized compounds were confirmed by analytical, spectral data & chemical tests. In-vivo anti-inflammatory activity of targeted compounds was tested against carrageenan-induced paw edema in albino rats. Half of the compounds exhibited appreciable activity when compared to reference drug.
Keywords :
Guanidinobenzoxazole , Pyrimidines , Pyrimidopyrimidines , Imidoxy derivatives , Biological activity
