Title of article :
Therapeutic effect of valsartan against doxorubicin-induced renal toxicity in rats
Author/Authors :
Li, Qi-Xiong Department of Pharmacology - City College - Wuhan University of Science and Technology - Wuhan, China , Liu, Hai-Xia Department of Pharmacology - City College - Wuhan University of Science and Technology - Wuhan, China , Li, Jin Department of Laboratory - Zhongnan Hospital of Wuhan University - Wuhan, China
Abstract :
Doxorubicin (DXR)-induces glomerular atrophy and fibrosis in rat kidneys. The objective
of the current study was to investigate the protective effects of valsartan on DXR-induced glomerular
toxicity and its mechanisms of actions in rats.
Materials and Methods: Male Sprague-Dawley (SD) rats were divided into four groups, and each group
contains ten rats. First group was control and was treated with saline only. Treatment groups were injected
with DXR (6.5 mg/kg) alone, or intragastric gavage with 10 mg/kg or 20 mg/kg of valsartan after DXR
treatment.
Results: Rats treated with DXR only showed significant changes in concentrations of urinary protein,
serum creatinine (SCr), and blood urea nitrogen (BUN). Moreover, glomerular structural damages
were observed in rats treated with DXR. Valsartan significantly alleviated the effect of DXR. Dramatic
elevation in malondialdehyde (MDA), nitric oxide (NO), nitric oxide synthase (NOS) and significant
reductions in the levels of reduced glutathione (GSH), glutathione peroxidase (GPx), superoxide
dismutase (SOD) were seen after DXR treatment. These effects were effectively ameliorated by coadministration
with valsartan.
Conclusion: The findings of our study indicate that valsartan may play an important role in protecting
DXR-induced renal toxicity, at least in part, through its antioxidant properties.
Keywords :
Antioxidants , Doxorubicin , Histopathology , Nephrotoxicity , Valsartan
Journal title :
Astroparticle Physics