Title of article :
Successful Treatment of Fungal Osteomyelitis with Voriconazole in a Patient with CGD
Author/Authors :
Mohammadpour, Masoud Department of Pediatrics - Tehran University of Medical Sciences , Mamishi, Setareh Department of Pediatrics - Tehran University of Medical Sciences , Oaji, Mahsa Children’s Medical Center - Pediatrics Center of Excellence - Tehran University of Medical Sciences , Pourpak, Zahra Immunology - Asthma and Allergy Research Institute - Tehran University of Medical Sciences , Parvaneh, Nima Department of Pediatrics - Tehran University of Medical Sciences
Abstract :
Background: Chronic granulomatous disease (CGD) is an immunodeficiency affecting phagocytic leukocytes. Defective respiratory burst mechanism renders the affected patients to be susceptible to catalase positive microorganisms. With the great successes in antibacterial prophylaxis and therapy, fungal infections are a persistent problem. Invasive aspergillosis is the most important cause of mortality in CGD.
Case Presentation: We describe a nine year-old boy with CGD who presented with aspergillus induced skull osteomyelitis. He was successfully treated with voriconazole after initial failure of amphotericin B therapy.
Conclusion: Currently, newer triazoles are recommended as initial therapy for invasive aspergillosis in immunodeficiency states such as CGD.
Keywords :
Granulomatous disease , Invasive Pulmonary Aspergillosis , Voriconazole , Fungal Infections , Osteomyelitis
Journal title :
Astroparticle Physics
