Title of article :
The IRX3 Gene; the Missing Link between the FTO Gene and Obesity
Author/Authors :
Doaei ، Saeid - Shahid Beheshti University of Medical Sciences , Gholamalizadeh ، Maryam - Shahid Beheshti University of Medical Sciences , Mosavi Jarrahi ، Alireza - Shahid Beheshti University of Medical Sciences , Badakhanian ، Marjan - Isfahan University of Medical Sciences , Najafi ، Rahim Urmia University of Medical Sciences
Abstract :
Aims: The aim of this study was the investigation of the mediator role of the IRX3 gene in the relationship between the FTO gene and obesity. Materials and Methods: All related articles published in English from June 1990 to February 2017 were studied. Results: Only a Few studies have examined the association between the IRX3 gene with the FTO gene and obesity. However, all of them reported that the FTO gene can influence the IRX3 gene expression. Also, it’s reported that the IRX3 gene expression level has a significant association with body weight and body composition. Conclusions: The FTO gene effects on obesity is in part due to its impact on the IRX3 gene expression level. The further studies are needed to investigate this interaction and clarify the existing mechanisms
Keywords :
IRX3 gene , the FTO gene , obesity
Journal title :
Asian Pacific Journal of Cancer Biology
Journal title :
Asian Pacific Journal of Cancer Biology