Abstract :
In recent years the science of tissue engineering has emerged as a powerful tool for the development of a
novel set of tissue replacement parts and technologies. Recent advances in the fields of biomaterials,
stem cell technologies, growth factor field and biomimetics have created a unique set of opportunities
for investigators to fabricate lab-grown tissues from combination of extracellular matrices (scaffolds),
cells, and bioactive molecules. Despite these breakthrough advances, the major challenges facing this
new emerging field of bioengineering remain unresolved as lab-grown tissues still exhibit a general lack
of functional and biomechanical stability needed for transplantation. A successful strategy to develop
true human replacement parts requires a multidisciplinary approach that converges recent advances in
tissue, matrix, growth factor and developmental biology with recent technological breakthroughs in
tissueinformatics, bioinformatics, highthrouput combinatorial chemistry and stem cell technologies
Keywords :
Extracellular matrices , Stem cells , Biomaterial , Tissue engineering , Growth factors