Author/Authors :
Hallaji, Zahra Autoimmune Bullous Disease Research Center - Tehran University of Medical Sciences, Tehran , Lajevardi, Vahideh Autoimmune Bullous Disease Research Center - Tehran University of Medical Sciences, Tehran , Abedini, Robabeh Autoimmune Bullous Disease Research Center - Tehran University of Medical Sciences, Tehran , Soleymani, Amir Autoimmune Bullous Disease Research Center - Tehran University of Medical Sciences, Tehran , Goodarzi, Azadeh Department of Dermatology - Iran University of Medical Sciences, Tehran , Salehi-Taleghani, Mehrnaz Department of Dermatology - Zanjan University of Medical Sciences, Zanjan , Beygi, Sara Autoimmune Bullous Disease Research Center - Tehran University of Medical Sciences, Tehran
Abstract :
Background: The prevalence of non-alcoholic fatty liver disease is
higher in patients with psoriasis than in the normal population.
Serum leptin levels are higher in patients with psoriasis and in
patients with non-alcoholic fatty liver. The purpose of this study
was to determine the serum levels of leptin in psoriatic patients
with and without non-alcoholic fatty liver.
Methods: This cross-sectional study was conducted at Razi
Dermatology Hospital, Tehran, Iran in 2013. A total of 50 patients
with psoriasis were enrolled in the study. Fatty liver grade was
assessed via ultrasonography and serum leptin levels were
measured using the ELISA method.
Results: Ten patients had normal livers and 40 had fatty livers
with different grades. The median serum leptin level was
significantly higher in psoriatic patients with fatty liver (11.75
ng/mL) in comparison to those without fatty liver (2.80 ng/ml).
Moreover, there was a direct correlation between the leptin level
and the grade of fatty liver.
Conclusion: serum leptin can be elevated in the course of psoriasis
and may have a role in the pathogenesis of non-alcoholic fatty liver
disease and other metabolic co morbidities in psoriatic patients.
