Title of article :
Prevalence and Antimicrobial Resistance of Bacterial Uropathogens Isolated from Iranian Kidney Transplant Recipients: A Systematic Review and Meta-Analysis
Author/Authors :
SHAPOURI MOGHADDAM ، Abbas Department of Immunology - BuAli Research Institute, Faculty of Medicine - Mashhad University of Medical Sciences , ARFAATABAR ، Maryam Department of Medical Laboratory Sciences - Islamic Azad University, Kashan Branch , TAVAKOL AFSHARI ، Jalil Department of Immunology - BuAli Research Institute, Faculty of Medicine - Mashhad University of Medical Sciences , SHAKERIMOGHADDAM ، Ali Department of Microbiology and Immunology - Infectious Diseases Research Center, School of Medicine - Kashan University of Medical Sciences , MOHAMMADZAMANI ، Zahra Department of Microbiology and Immunology - Infectious Diseases Research Center, School of Medicine - Kashan University of Medical Sciences , KHALEDI ، Azad Department of Microbiology and Immunology - Infectious Diseases Research Center, School of Medicine - Kashan University of Medical Sciences
Pages :
12
From page :
2165
To page :
2176
Abstract :
Background: Urinary tract infection (UTI) is a major complication in patients who receive the kidney trans-plant. We aimed to evaluate the prevalence and antimicrobial resistance of bacterial uropathogens isolated from Iranian kidney transplant recipients. Methods: We searched according to Prisma protocol for UTI infection, prevalence, occurrence and distribu-tion of bacteria and their pattern of antibiotic resistance among Iranian patients who receive kidney transplant through online electronic databases with MeSh terms and text words in published references in both Persian and English languages during 1990-2017. Data analysis was performed using Comprehensive meta-analysis software (CMA) by Cochrane Q and I2 Random Effects Model. Results: Eleven studies met the eligible inclusion criteria. The prevalence of UTI among kidney transplant patients varied from 11.7% to 67.5%. The combined prevalence of UTI was 32.6%. Among Gram-negative pathogens causing UTI, E. coli was the most dominant followed by Klebsiella pneumonia with prevalence 41.3% and 11.9%, respectively. Also, amongst Gram-positive bacteria, the highest prevalence belonged to Enterococcus spp. (9.8%) and coagulase-negative Staphylococci (9.4%). Also in Gram-negative pathogens, the most re-sistance was to ampicillin (91.2%), followed by ceftazidime (89.5%). The minimum resistance was against imipenem with prevalence 14.3%. Conclusion: The combined prevalence of UTI was 32.6%. Gram-negative pathogens especially E. coli were the most agents of UTI in Iranian patients who receive kidney transplant. Also, in gram-negative pathogens, the most resistance was to ampicillin that it needs a new strategy for prophylaxis and treatment of UTI after the kidney transplant.
Keywords :
Kidney transplant , Urinary tract infection , Iran
Journal title :
Iranian Journal of Public Health
Serial Year :
2019
Journal title :
Iranian Journal of Public Health
Record number :
2484154
Link To Document :
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