Title of article :
Investigating the Relationship between Magnesium levels and Diabetes Mellitus in Pregnant Women
Author/Authors :
Musavi, Hadis Babol University of Medical Sciences, Babol , Mohammadi Tahroodi, Fariba Department of Biochemistry - School of Medicine - Kerman University of Medical Sciences, Kerman , Fesahat, Farzaneh Reproductive Immunology Research Center - Shahid Sadoghi University of Medical Sciences, Yazd , Bouzari, Zinatossadat Infertility and Reproductive Health Research Center - Health Research Institute - Babol University of Medical Sciences, Babol , Esmaeilzadeh, Seddigheh Department of Obstetrics and Gynecology - School of Medicine - Infertility and Reproductive Health Research Center Fatima Al-Zahra Research Center for Fertility and Infertility - Babol University of Medical Sciences, Babol , Elmi, Fatemeh Babol University of Medical Sciences, Babol , Yazdani, Shahla Department of Internal Medicine - Babol University of Medical Sciences, Babol , Moazezi, Zoleika Department of Endocrinology - Babol University of Medical Sciences, Babol
Abstract :
Gestational diabetes mellitus (GDM) is defined as one of the three main types of diabetes mellitus (DM). It is established that GDM is associated with exceeding nutrient losses owing to glycosuria. Magnesium (Mg), as one of the essential micronutrients for fetus development, acts as the main cofactor in most enzymatic processes. The aim of this study was to measure serum and cellular levels of Mg, albumin, creatinine, and total protein to further clarify the relationship between these components and DM in pregnant women. Blood samples were obtained from 387 pregnant women. The participants were classified into four groups based on their type of diabetes, namely GDM (n=96), DM (n=44), at high-risk of DM (n=122), and healthy controls (n=125). All participants' fasting blood sugar (FBS), creatinine, albumin, Mg, and total protein in the serum levels and red blood cell Mg (RBC-Mg) were measured during 24-28 weeks of gestation. Groups were compared for a possible association between DM and abortion, gravidity, and parity. The serum levels of creatinine, FBS, albumin, Mg, and RBC-Mg were statistically different among the four groups (P = 0.001). Significant lower levels of RBC-Mg was observed in all studied groups in comparison with controls. Given a positive correlation between DM and abortion, it seems that decreased levels of RBC-Mg and serum albumin can increase the risk of abortion in pregnant women. Our data demonstrated significant alterations in albumin, Mg, and creatinine concentrations in women with DM or those at high risk of DM during their gestational age. It seems that the measurement of these biochemical parameters might be helpful for preventing the complications, and improving pregnancies outcomes complicated with DM.
Keywords :
Gestational diabetes mellitus , Magnesium serum , Albumin , Diabetes mellitus , Pregnancy
Journal title :
Astroparticle Physics